| Alternative Names | IL12B, CLMF, CLMF2, NKSF, NKSF2, p40 |
| Source | Cynomolgus IL-12B Protein; His Tag (GM-88974RP) is expressed from human 293 cells (HEK-293). It contains AA Ile 23 - Ser 328 (Accession # A0A2K5TM36). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 35.6 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.2–7.4. |
| Description | L-12B (Interleukin-12B) is a crucial cytokine involved in the regulation of immune responses. It is primarily produced by immune cells such as macrophages and dendritic cells. IL-I12B forms a part of the heterodimeric cytokine IL-12, which plays a key role in promoting the activation of T cells and natural killer (NK) cells, thereby enhancing the body's ability to fight infections and tumors. The IL-12B gene encodes the p40 subunit, which combines with the p35 subunit (encoded by IL-12A) to form active IL-12. Besides its immune-stimulating functions, IL-12B is also involved in inflammation regulation and immune-related diseases. Variations or dysregulation of IL-12B have been linked to various autoimmune and inflammatory conditions, making it an important target for immunotherapy research. |
| Alternative Names | IL12B, CLMF, CLMF2, NKSF, NKSF2, p40 |
| Source | Cynomolgus IL-12B Protein; His Tag (GM-88974RP) is expressed from human 293 cells (HEK-293). It contains AA Ile 23 - Ser 328 (Accession # A0A2K5TM36). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 35.6 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.2–7.4. |
| Description | L-12B (Interleukin-12B) is a crucial cytokine involved in the regulation of immune responses. It is primarily produced by immune cells such as macrophages and dendritic cells. IL-I12B forms a part of the heterodimeric cytokine IL-12, which plays a key role in promoting the activation of T cells and natural killer (NK) cells, thereby enhancing the body's ability to fight infections and tumors. The IL-12B gene encodes the p40 subunit, which combines with the p35 subunit (encoded by IL-12A) to form active IL-12. Besides its immune-stimulating functions, IL-12B is also involved in inflammation regulation and immune-related diseases. Variations or dysregulation of IL-12B have been linked to various autoimmune and inflammatory conditions, making it an important target for immunotherapy research. |
