| Alternative Names | DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
| Source | Cynomolgus IL-1RL1(IL-33R) Protein; His Tag is expressed from human 293 cells (HEK-293). It contains AA Ala18-Cys331 (Accession # A0A2K5UDB8).This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 36.5 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.2–7.4. |
| Description | IL-1RL1 (also known as ST2) is a transmembrane receptor of the interleukin-1 receptor superfamily, expressed on mast cells, Th2 cells, and innate lymphoid cells (ILC2s). It binds to its ligand IL-33 on epithelial cells and endothelial cells, promoting type 2 immune responses, eosinophilic inflammation, and tissue repair in allergic and inflammatory conditions. In summary, IL-1RL1 is a key receptor for IL-33 signaling with biomarker and therapeutic potential in asthma, atopic dermatitis, and cardiovascular diseases. |
| Alternative Names | DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
| Source | Cynomolgus IL-1RL1(IL-33R) Protein; His Tag is expressed from human 293 cells (HEK-293). It contains AA Ala18-Cys331 (Accession # A0A2K5UDB8).This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 36.5 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.2–7.4. |
| Description | IL-1RL1 (also known as ST2) is a transmembrane receptor of the interleukin-1 receptor superfamily, expressed on mast cells, Th2 cells, and innate lymphoid cells (ILC2s). It binds to its ligand IL-33 on epithelial cells and endothelial cells, promoting type 2 immune responses, eosinophilic inflammation, and tissue repair in allergic and inflammatory conditions. In summary, IL-1RL1 is a key receptor for IL-33 signaling with biomarker and therapeutic potential in asthma, atopic dermatitis, and cardiovascular diseases. |
