| Alternative Names | NECTIN4, LNIR, PRR4, PVRL4 |
| Source | Human Nectin-4 Protein; hFc Tag (GM-88678RP) is expressed from human 293 cells (HEK-293). It contains AA Gly 32 - Ser 349 (Accession # Q96NY8-1). This protein carries a hFc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 60.1 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | Nectin-4 protein, full name Nectin Cell Adhesion Molecule 4, also known as Poliovirus Receptor-Related Protein 4 (PVRL4), is an important cell adhesion molecule and a member of the nectin family of immunoglobulin-like adhesion proteins. Abnormal expression of Nectin-4 protein is closely associated with the occurrence, progression, and metastasis of various malignant tumors, including breast cancer, lung cancer, ovarian cancer, pancreatic cancer, and urothelial carcinoma. Currently, Nectin-4-targeted therapeutic strategies have shown significant clinical promise, with the antibody-drug conjugate (ADC) Enfortumab Vedotin being approved for the treatment of locally advanced or metastatic urothelial carcinoma. In summary, Nectin-4 protein plays a pivotal role in tumorigenesis and cancer progression, and holds great significance for understanding tumor biology, identifying novel therapeutic targets, developing targeted ADCs and immunotherapies, and evaluating patient prognosis. |
| Alternative Names | NECTIN4, LNIR, PRR4, PVRL4 |
| Source | Human Nectin-4 Protein; hFc Tag (GM-88678RP) is expressed from human 293 cells (HEK-293). It contains AA Gly 32 - Ser 349 (Accession # Q96NY8-1). This protein carries a hFc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 60.1 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | Nectin-4 protein, full name Nectin Cell Adhesion Molecule 4, also known as Poliovirus Receptor-Related Protein 4 (PVRL4), is an important cell adhesion molecule and a member of the nectin family of immunoglobulin-like adhesion proteins. Abnormal expression of Nectin-4 protein is closely associated with the occurrence, progression, and metastasis of various malignant tumors, including breast cancer, lung cancer, ovarian cancer, pancreatic cancer, and urothelial carcinoma. Currently, Nectin-4-targeted therapeutic strategies have shown significant clinical promise, with the antibody-drug conjugate (ADC) Enfortumab Vedotin being approved for the treatment of locally advanced or metastatic urothelial carcinoma. In summary, Nectin-4 protein plays a pivotal role in tumorigenesis and cancer progression, and holds great significance for understanding tumor biology, identifying novel therapeutic targets, developing targeted ADCs and immunotherapies, and evaluating patient prognosis. |
