| Alternative Names | DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
| Source | Human IL-1RL1(IL-33R)Protein; His Tag (GM-88671RP) is expressed from human 293 cells (HEK-293). It contains AA Lys 19 - Pro 323 (Accession # NP_003847). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 35.2 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-1RL1 protein, full name Interleukin-1 Receptor-Like 1, also known as ST2, is an important cell surface transmembrane receptor protein and a member of the Toll-like/IL-1 receptor (TIR) superfamily. Abnormal expression or dysregulated signaling of IL-1RL1 protein is closely associated with the pathogenesis and progression of various inflammatory, fibrotic, and allergic diseases, particularly asthma, atopic dermatitis, idiopathic pulmonary fibrosis, and cardiovascular diseases. Currently, several IL-1RL1-targeted therapeutic strategies have been developed or are under clinical investigation. These include monoclonal antibodies such as Etokimab and Itepekimab, which block IL-33 binding to IL-1RL1; and biosimilar antibodies targeting the IL-33/ST2 axis, which aim to reduce inflammation and improve clinical outcomes for patients with allergic, inflammatory, and fibrotic diseases. In summary, IL-1RL1 protein plays a pivotal role in the development and progression of inflammatory, fibrotic, and allergic diseases, and is of great significance for understanding disease pathogenesis, selecting targeted treatment strategies, and evaluating patient prognosis. |
| Alternative Names | DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
| Source | Human IL-1RL1(IL-33R)Protein; His Tag (GM-88671RP) is expressed from human 293 cells (HEK-293). It contains AA Lys 19 - Pro 323 (Accession # NP_003847). This protein carries a His tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 35.2 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-1RL1 protein, full name Interleukin-1 Receptor-Like 1, also known as ST2, is an important cell surface transmembrane receptor protein and a member of the Toll-like/IL-1 receptor (TIR) superfamily. Abnormal expression or dysregulated signaling of IL-1RL1 protein is closely associated with the pathogenesis and progression of various inflammatory, fibrotic, and allergic diseases, particularly asthma, atopic dermatitis, idiopathic pulmonary fibrosis, and cardiovascular diseases. Currently, several IL-1RL1-targeted therapeutic strategies have been developed or are under clinical investigation. These include monoclonal antibodies such as Etokimab and Itepekimab, which block IL-33 binding to IL-1RL1; and biosimilar antibodies targeting the IL-33/ST2 axis, which aim to reduce inflammation and improve clinical outcomes for patients with allergic, inflammatory, and fibrotic diseases. In summary, IL-1RL1 protein plays a pivotal role in the development and progression of inflammatory, fibrotic, and allergic diseases, and is of great significance for understanding disease pathogenesis, selecting targeted treatment strategies, and evaluating patient prognosis. |
