| Alternative Names | FBP, FOLR, FRα |
| Source | Human FOLR1 Protein; hFc Tag (GM-87509RP) is expressed from human 293 cells (HEK-293). It contains AA Arg 25 - Met 233 (Accession # P15328-1). This protein carries a hFc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 50.5 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | FOLR1 protein is a folate-binding protein that belongs to the folate receptor (FR) family. It is encoded by the FOLR1 gene and is a protein associated with cellular folate uptake and metabolism. FOLR1 protein was initially identified in placental and renal tissues and later detected in various epithelial tissues and cancer cells. FOLR1 protein regulates the cellular internalization of folate and its derivatives by binding to folic acid with high affinity, facilitating one-carbon transfer reactions essential for nucleotide synthesis and DNA replication. Epithelial cells are important components of many organs, with critical functions in nutrient absorption, barrier maintenance, and tissue homeostasis, making them fundamental members of normal physiology. Research indicates that FOLR1 protein plays a significant role in supporting rapid cell division, maintaining cellular metabolism, and modulating tumor progression. Additionally, the expression of FOLR1 protein is associated with ovarian cancer, lung cancer, and other malignant diseases, as well as folate transport disorders, making it a potential target for cancer diagnosis and targeted therapy. |
| Alternative Names | FBP, FOLR, FRα |
| Source | Human FOLR1 Protein; hFc Tag (GM-87509RP) is expressed from human 293 cells (HEK-293). It contains AA Arg 25 - Met 233 (Accession # P15328-1). This protein carries a hFc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 50.5 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | FOLR1 protein is a folate-binding protein that belongs to the folate receptor (FR) family. It is encoded by the FOLR1 gene and is a protein associated with cellular folate uptake and metabolism. FOLR1 protein was initially identified in placental and renal tissues and later detected in various epithelial tissues and cancer cells. FOLR1 protein regulates the cellular internalization of folate and its derivatives by binding to folic acid with high affinity, facilitating one-carbon transfer reactions essential for nucleotide synthesis and DNA replication. Epithelial cells are important components of many organs, with critical functions in nutrient absorption, barrier maintenance, and tissue homeostasis, making them fundamental members of normal physiology. Research indicates that FOLR1 protein plays a significant role in supporting rapid cell division, maintaining cellular metabolism, and modulating tumor progression. Additionally, the expression of FOLR1 protein is associated with ovarian cancer, lung cancer, and other malignant diseases, as well as folate transport disorders, making it a potential target for cancer diagnosis and targeted therapy. |
