| Species Reactivity | Human; Cynomolgus |
| Clone | 41683 |
| Source/Isotype | Human IgG1(M252Y, S254T, T256E, R292C, N297G, V302C, D356E, L358M, L234A, L235A, P329G), Kappa |
| Application | Flow Cytometry; Bioactivity-ELISA |
| Specificity | Detects CD30L |
| Gene | CD30L |
| Other Names | CD30-L,CD153,TNFSF8,CD30L,CD30LG,CD153 antigen,CD30 antigen ligand,CD30 Ligand |
| Gene ID | 944 (human); 102143966 (Cynomolgus) |
| Background | CD30L gene (encoding CD153/TNFSF8 protein) is a key member of the tumor necrosis factors superfamily. As a ligand of CD30(TNFRSF8), it plays a dual role in immune regulation and tumorigenesis. The type II transmembrane glycoprotein encoded by this gene is mainly expressed on the surface of activated T cells, B cells, macrophages and some tumor cells, and activates NF-κb, MAPK and other signaling pathways by binding to CD30, it regulates lymphocyte activation, proliferation, apoptosis and immunoglobulin class switching. Under normal physiological conditions, CD30L is involved in T-B cell interaction and immune surveillance; under pathological conditions, CD30L is involved in T-B cell interaction and immune surveillance, its abnormal expression is closely related to Hodgkin's lymphoma (HL) , anaplastic large cell lymphoma (ALCL) , adult T cell leukemia/lymphoma (ATL) , diffuse large B cell lymphoma (DLBCL) and other lymphomas and autoimmune diseases. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human; Cynomolgus |
| Clone | 41683 |
| Source/Isotype | Human IgG1(M252Y, S254T, T256E, R292C, N297G, V302C, D356E, L358M, L234A, L235A, P329G), Kappa |
| Application | Flow Cytometry; Bioactivity-ELISA |
| Specificity | Detects CD30L |
| Gene | CD30L |
| Other Names | CD30-L,CD153,TNFSF8,CD30L,CD30LG,CD153 antigen,CD30 antigen ligand,CD30 Ligand |
| Gene ID | 944 (human); 102143966 (Cynomolgus) |
| Background | CD30L gene (encoding CD153/TNFSF8 protein) is a key member of the tumor necrosis factors superfamily. As a ligand of CD30(TNFRSF8), it plays a dual role in immune regulation and tumorigenesis. The type II transmembrane glycoprotein encoded by this gene is mainly expressed on the surface of activated T cells, B cells, macrophages and some tumor cells, and activates NF-κb, MAPK and other signaling pathways by binding to CD30, it regulates lymphocyte activation, proliferation, apoptosis and immunoglobulin class switching. Under normal physiological conditions, CD30L is involved in T-B cell interaction and immune surveillance; under pathological conditions, CD30L is involved in T-B cell interaction and immune surveillance, its abnormal expression is closely related to Hodgkin's lymphoma (HL) , anaplastic large cell lymphoma (ALCL) , adult T cell leukemia/lymphoma (ATL) , diffuse large B cell lymphoma (DLBCL) and other lymphomas and autoimmune diseases. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
