| Alternative Names | IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
| Source | Human IL-1RL1(IL-33R) Protein; hFc Tag (GM-88162RP) is expressed from human 293 cells (HEK-293). It contains AA Lys 19 - Pro 323 (Accession # NP_003847). This protein carries a human IgG1 Fc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 60.3 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-1 receptor-like 1 (IL1RL1), known as ST2, belongs to the IL-1 receptor superfamily. ST2 has two main isoforms: transmembrane ST2L (receptor) and soluble sST2 (decoy regulating IL-33 signaling). IL1RL1/ST2 is mainly expressed in immune cells (Th2, mast cells, eosinophils, ILCs) and in endothelial/epithelial tissues. The ST2/IL-33 axis promotes type 2 immunity, tissue repair, and inflammation; its dysregulation links to asthma, allergic rhinitis, and cardiovascular diseases. IL-33 binding to ST2L recruits IRAK and MyD88, activating NF-κB, MAPKs (p38, JNK, ERK), and AP-1, driving transcription of type 2 cytokines (IL-4, IL-5, IL-13) and chemokines to recruit eosinophils and enhance mucus production. sST2 sequestration of IL-33 dampens ST2L signaling. Some ST2L-independent signaling occurs in certain cells, with crosstalk to other TLR/IL-1 pathways adding complexity. Dysregulated IL-33/ST2 signaling contributes to chronic inflammation and fibrosis, making it a therapeutic target. |
| Alternative Names | IL1RL1, DER4, FIT-1, IL33R, ST2, ST2L, ST2V, T1 |
| Source | Human IL-1RL1(IL-33R) Protein; hFc Tag (GM-88162RP) is expressed from human 293 cells (HEK-293). It contains AA Lys 19 - Pro 323 (Accession # NP_003847). This protein carries a human IgG1 Fc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 60.3 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-1 receptor-like 1 (IL1RL1), known as ST2, belongs to the IL-1 receptor superfamily. ST2 has two main isoforms: transmembrane ST2L (receptor) and soluble sST2 (decoy regulating IL-33 signaling). IL1RL1/ST2 is mainly expressed in immune cells (Th2, mast cells, eosinophils, ILCs) and in endothelial/epithelial tissues. The ST2/IL-33 axis promotes type 2 immunity, tissue repair, and inflammation; its dysregulation links to asthma, allergic rhinitis, and cardiovascular diseases. IL-33 binding to ST2L recruits IRAK and MyD88, activating NF-κB, MAPKs (p38, JNK, ERK), and AP-1, driving transcription of type 2 cytokines (IL-4, IL-5, IL-13) and chemokines to recruit eosinophils and enhance mucus production. sST2 sequestration of IL-33 dampens ST2L signaling. Some ST2L-independent signaling occurs in certain cells, with crosstalk to other TLR/IL-1 pathways adding complexity. Dysregulated IL-33/ST2 signaling contributes to chronic inflammation and fibrosis, making it a therapeutic target. |
