| Alternative Names | IL22RA2, CRF2-S1, CRF2-10, CRF2-S1 |
| Source | Human IL-22BP Protein; His Tag (GM-88673RP) is expressed from human 293 cells (HEK-293). It contains AA Thr 22 - Pro 231 (Accession # Q969J5-2). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 25.5 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.2–7.4. |
| Description | IL-22 Binding Protein (IL22BP) is a soluble receptor belonging to the IL-10 receptor family, encoded by the IL22RA2 gene. It specifically binds to the cytokine IL-22 with high affinity and negatively regulates IL-22's biological functions by competitively inhibiting its interaction with the membrane-bound signaling receptor complex (composed of IL-10R2 and IL-22R1). IL22BP itself does not directly transduce signals but indirectly modulates downstream pathways by neutralizing IL-22. Upon binding to IL-22, it prevents the activation of the JAK-STAT signaling pathway (primarily involving phosphorylation of JAK1/TYK2 kinases and subsequent STAT3 activation). This inhibition blocks the nuclear translocation of STAT3 and its initiation of target gene transcription, ultimately suppressing IL-22-mediated effects such as epithelial cell proliferation, antimicrobial peptide production, and mucosal barrier repair. Thus, IL22BP serves as a crucial upstream regulator of the IL-22/STAT3 pathway. |
| Alternative Names | IL22RA2, CRF2-S1, CRF2-10, CRF2-S1 |
| Source | Human IL-22BP Protein; His Tag (GM-88673RP) is expressed from human 293 cells (HEK-293). It contains AA Thr 22 - Pro 231 (Accession # Q969J5-2). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 25.5 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.2–7.4. |
| Description | IL-22 Binding Protein (IL22BP) is a soluble receptor belonging to the IL-10 receptor family, encoded by the IL22RA2 gene. It specifically binds to the cytokine IL-22 with high affinity and negatively regulates IL-22's biological functions by competitively inhibiting its interaction with the membrane-bound signaling receptor complex (composed of IL-10R2 and IL-22R1). IL22BP itself does not directly transduce signals but indirectly modulates downstream pathways by neutralizing IL-22. Upon binding to IL-22, it prevents the activation of the JAK-STAT signaling pathway (primarily involving phosphorylation of JAK1/TYK2 kinases and subsequent STAT3 activation). This inhibition blocks the nuclear translocation of STAT3 and its initiation of target gene transcription, ultimately suppressing IL-22-mediated effects such as epithelial cell proliferation, antimicrobial peptide production, and mucosal barrier repair. Thus, IL22BP serves as a crucial upstream regulator of the IL-22/STAT3 pathway. |
