| Species Reactivity | Human |
| Clone | HER2/5C7 |
| Source/Isotype | Human IgG1(hole/knob), Kappa |
| Application | Flow Cytometry; Activation assay |
| Specificity | Detects CLEC5A、HER2 |
| Gene | CLEC5A&HER2 |
| Other Names | CLEC5A: CLECSF5, MDL-1, MDL1 HER2: CD340, HER-2, HER-2/neu, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) |
| Gene ID | CLEC5A: 23601 (human) HER2: 2064 (human) |
| Background | CLEC5A, a member of the C-type lectin family, acts as a macrophage surface receptor and participates in the immune response by triggering pro-inflammatory signals in viral infections such as dengue fever, and it has been implicated in the pathogenesis of dengue fever, it is also closely related to inflammatory diseases such as sepsis and systemic lupus erythematosus, and is an important tumor treatment target. CLEC5A × HER2 biantibody can not only block HER2-mediated tumor signaling pathway, but also regulate CLEC5A-related inflammatory response by simultaneously binding CLEC5A and HER2 targets, enhancing anti-tumor activity while reducing immune-related side effects provides a novel therapeutic strategy for HER2-positive tumors and CLEC5A-overexpressing inflammatory diseases. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human |
| Clone | HER2/5C7 |
| Source/Isotype | Human IgG1(hole/knob), Kappa |
| Application | Flow Cytometry; Activation assay |
| Specificity | Detects CLEC5A、HER2 |
| Gene | CLEC5A&HER2 |
| Other Names | CLEC5A: CLECSF5, MDL-1, MDL1 HER2: CD340, HER-2, HER-2/neu, MLN 19, MLN-19, NEU, NGL, TKR1, VSCN2, c-ERB-2, c-ERB2, p185(erbB2) |
| Gene ID | CLEC5A: 23601 (human) HER2: 2064 (human) |
| Background | CLEC5A, a member of the C-type lectin family, acts as a macrophage surface receptor and participates in the immune response by triggering pro-inflammatory signals in viral infections such as dengue fever, and it has been implicated in the pathogenesis of dengue fever, it is also closely related to inflammatory diseases such as sepsis and systemic lupus erythematosus, and is an important tumor treatment target. CLEC5A × HER2 biantibody can not only block HER2-mediated tumor signaling pathway, but also regulate CLEC5A-related inflammatory response by simultaneously binding CLEC5A and HER2 targets, enhancing anti-tumor activity while reducing immune-related side effects provides a novel therapeutic strategy for HER2-positive tumors and CLEC5A-overexpressing inflammatory diseases. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
