| Cat. No: GM-C15426 Product: H_TLR7 Reporter 293 Cell Line TLR7 (Toll-like receptor 7) is an intracellular pattern recognition receptor that primarily detects single-stranded RNA (ssRNA), particularly viral RNA. It is expressed in immune cells like dendritic cells, macrophages, and B cells, contributing to the innate immune response and antiviral immunity by activating the immune system and promoting inflammatory responses and interferon production. The TLR7 signaling pathway is activated when ssRNA binds to TLR7, recruiting the adaptor protein MyD88, which triggers downstream signaling. This pathway activates transcription factors such as NF-κB and IRF7, leading to the expression of interferons and other cytokines. Thus, TLR7 is crucial for regulating immune responses and antiviral defense. H_TLR7 Reporter 293 Cell Line is a clonal stable HEK-293 cell line constructed using lentiviral technology, constitutive expression of the TLR7 gene, along with signal-dependent expression of a luciferase reporter gene. When Resiquimod binds to TLR7, it activates downstream signaling pathways, leading to the expression of luciferase. The luciferase activity measurement indicates the activation level of the signaling pathway and can thus be used to evaluate the in vitro effects of drugs related to TLR7. |  |
