当前位置:产品中心 > 抗体 > ADC类抗体 > 抗毒素抗体 > Anti-MMAE Mouse IgG2a Antibody (8F6A3)
Anti-MMAE Mouse IgG2a Antibody (8F6A3)
基本信息

产品编号:GM-81238AB

产品名称:Anti-MMAE Mouse IgG2a Antibody (8F6A3)

目录价:询价


产品配图.jpg

规格货号

GM-81238AB-100        100μg

GM-81238AB-1000      1mg

产品简介

Expression System     CHO

Aggregation               < 5% as determined by SEC-HPLC

Purity                          >95% as determined by SDS-PAGE

Endotoxin                  <1 EU/mg by LAL

Sterility                        0.2 μm Filtered

Target                          MMAE

Clone                           8F6A3

Alternative Names     /

Source/lsotype           Monoclonal Mouse IgG2a,κ

Application                 ELISA, PK

Description                 Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.

Formulation                Dulbecco's phosphate-buffered solution, pH 7.4.

Storage temp.             Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

数据展示

GM-81238AB-1.png


GM-81238AB-2.png

当前位置:产品中心 > 抗体 > ADC类抗体 > Anti-MMAE Mouse IgG2a Antibody (8F6A3)

Anti-MMAE Mouse IgG2a Antibody (8F6A3)
基本信息

产品编号:GM-81238AB

产品名称:Anti-MMAE Mouse IgG2a Antibody (8F6A3)

目录价:询价


产品配图.jpg

规格货号

GM-81238AB-100        100μg

GM-81238AB-1000      1mg

产品简介

Expression System     CHO

Aggregation               < 5% as determined by SEC-HPLC

Purity                          >95% as determined by SDS-PAGE

Endotoxin                  <1 EU/mg by LAL

Sterility                        0.2 μm Filtered

Target                          MMAE

Clone                           8F6A3

Alternative Names     /

Source/lsotype           Monoclonal Mouse IgG2a,κ

Application                 ELISA, PK

Description                 Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. Monomethyl auristatin E is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin. The linker to the monoclonal antibody is stable in extracellular fluid but is cleaved by cathepsin once the conjugate has entered a tumor cell, thus activating the antimitotic mechanism.

Formulation                Dulbecco's phosphate-buffered solution, pH 7.4.

Storage temp.             Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

数据展示

GM-81238AB-1.png


GM-81238AB-2.png

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