H_IL-31RA OSMR Baf3 Cell Line

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H_IL-31RA OSMR Baf3 Cell Line

说明书

货号

GM-C29783

规格

1管

立即询价

基本信息

数据展示

细胞培养、冻存、复苏试剂准备

相关产品

基本信息

白细胞介素-31（IL-31）是一种新型细胞因子，其受体与IL-6受体相似，因此归属于IL-6细胞因子家族。其主要由活化的CD4+T淋巴细胞分泌，特别是活化的辅助性Th2细胞、肥大细胞、巨噬细胞以及树突状细胞等。IL-31主要通过感知周围神经系统的瘙痒来调节皮肤中细胞介导的免疫力，通过增加气道炎症调节肺部的免疫力，并通过防御微生物来调节肠道中的免疫力。

IL-31通过IL31RA和OSMR(oncostatin M receptor)受体形成异源二聚体复合物传递信号。其信号通路与慢性瘙痒性皮肤病（如特应性湿疹）密切相关。针对IL-31或IL-31受体的单克隆抗体相关药物可以有效地减少瘙痒和睡眠障碍，改善皮肤病变，并最大限度地减少局部类固醇的使用。

BA/F3细胞是一种依赖于IL-3的前体B细胞。IL-31蛋白可以替代IL-3，使Ba/F3细胞依赖于它进行生长。当使用与IL-31相关的拮抗剂阻断此作用后，细胞会出现浓度依赖的死亡。因此，可以通过测定细胞活力来评价IL-31相关抑制剂的活性。

数据展示

应用

表达

细胞培养、冻存、复苏试剂准备

细胞生长培养基： RPMI 1640+10% FBS+1% P.S+8 ng/mL M_IL3+50 μg/mL G418+0.25 μg/mL Puromycin

细胞冻存液： 90% FBS+10% DMSO

Assay Buffer： RPMI 1640+10% FBS+1% P.S

细胞生长培养基： RPMI 1640+10% FBS+1% P.S+8 ng/mL M_IL3+50 μg/mL G418+0.25 μg/mL Puromycin

细胞冻存液： 90% FBS+10% DMSO

Assay Buffer： RPMI 1640+10% FBS+1% P.S

相关产品

OX40:OX40L
H_OX40 Reporter Cell Line	H_OX40 Reporter DDX35TM Cell Line	Cynomolgus_OX40 HEK-293 Cell Line
Cynomolgus_OX40L CHO-K1 Cell Line	H_OX40 CHO-K1 Cell Line	H_OX40L CHO-K1 Cell Line
H_OX40L HEK-293 Cell Line	Mouse_OX40L CHO-K1 Cell Line	Rat_OX40L CHO-K1 Cell Line
Biotinylated Human OX40L Protein; His-Avi Tag	Cynomolgus OX40 Protein; His Tag	Cynomolgus OX40L Protein; His Tag
Cynomolgus OX40L Protein; mFc Tag	Human OX40 Protein; hFc Tag	Human OX40 Protein; His Tag
Human OX40L Protein; His Tag	Human OX40L Protein; mFc Tag
IL-4/IL-13
IL-4 Reporter Cell Line	IL-4/IL-13 Reporter 293 Cell Line	IL-4/IL-13 Reporter 293 DDX35TM Cell Line
Cynomolgus_IL4R CHO-K1 Cell Line	H_IL4R CHO-K1 Cell Line	H_IL4R CHO-K1 Cell Line (Low Expression)
H_IL4R HEK-293 Cell Line	Mouse_IL4R CHO-K1 Cell Line
Biotinylated Human IL-4R alpha Protein; Avi-His Tag	Cynomolgus IL-13 Protein; His Tag	Cynomolgus IL-13RA1 Protein; hFc Tag
Cynomolgus IL-13RA1 Protein; His Tag	Cynomolgus IL-4 Protein; His Tag	Cynomolgus IL-4R alpha Protein; His Tag
Human IL-13 Protein; His Tag	Human IL-13RA1 Protein; hFc Tag	Human IL-13RA1 Protein; His Tag
Human IL-4 Protein; His Tag	Human IL-4R alpha Protein; hFc Tag	Human IL-4R alpha Protein; His Tag
Human IL-4R alpha Protein; mFc Tag	Mouse IL-13 Protein; His Tag	Mouse IL-4R alpha Protein; His Tag
Rat IL-4R alpha Protein; His Tag
IL-31
Cynomolgus_IL-31RA OSMR Reporter Baf3 Cell Line	H_IL-31 Reporter Cell Line	H_IL-31 Reporter DDX35TM Cell Line
Cynomolgus_IL31RA CHO-K1 Cell Line	H_IL31RA CHO-K1 Cell Line	H_IL31RA HEK-293 Cell Line
H_IL-31RA OSMR CHO-K1 Cell Line
Cynomolgus IL-31 Protein; His Tag	Cynomolgus IL-31RA Protein; hFc Tag	Human IL-31 Protein; hFc Tag
Human IL-31 Protein; His Tag	Human IL-31RA Protein; hFc Tag
MRGPRX2
H_MRGPRX2 Gq Reporter CHO-K1 Cell Line	H_MRGPRX2 Gqi5 Reporter CHO-K1 Cell Line	Tango-H_MRGPRX2 CHO-K1 Cell Line
Cynomolgus_MRGPRX2 CHO-K1 Cell Line	Cynomolgus_MRGPRX2 HEK-293 Cell Line	Flag-Mouse_Mrgprb2 CHO-K1 Cell Line
Flag-Rat_Mrgprb3 HEK-293 Cell Line	H_MRGPRX2 CHO-K1 Cell Line	H_MRGPRX2 HEK-293 Cell Line
H_MRGPRX2 HMC-1 Cell Line	H_MRGPRX2 RBL-2H3 Cell Line

For laboratory research use only. Direct human use, including taking orally and injection and clinical use are forbidden.

H_IL-31RA OSMR Baf3 Cell Line

说明书

货号

GM-C29783

规格

1管

立即询价

基本信息

数据展示

细胞培养、冻存、复苏试剂准备

相关产品

基本信息

数据展示

应用

表达

细胞培养、冻存、复苏试剂准备

细胞生长培养基： RPMI 1640+10% FBS+1% P.S+8 ng/mL M_IL3+50 μg/mL G418+0.25 μg/mL Puromycin

细胞冻存液： 90% FBS+10% DMSO

Assay Buffer： RPMI 1640+10% FBS+1% P.S

细胞生长培养基： RPMI 1640+10% FBS+1% P.S+8 ng/mL M_IL3+50 μg/mL G418+0.25 μg/mL Puromycin

细胞冻存液： 90% FBS+10% DMSO

Assay Buffer： RPMI 1640+10% FBS+1% P.S

相关产品

OX40:OX40L
H_OX40 Reporter Cell Line	H_OX40 Reporter DDX35TM Cell Line	Cynomolgus_OX40 HEK-293 Cell Line
Cynomolgus_OX40L CHO-K1 Cell Line	H_OX40 CHO-K1 Cell Line	H_OX40L CHO-K1 Cell Line
H_OX40L HEK-293 Cell Line	Mouse_OX40L CHO-K1 Cell Line	Rat_OX40L CHO-K1 Cell Line
Biotinylated Human OX40L Protein; His-Avi Tag	Cynomolgus OX40 Protein; His Tag	Cynomolgus OX40L Protein; His Tag
Cynomolgus OX40L Protein; mFc Tag	Human OX40 Protein; hFc Tag	Human OX40 Protein; His Tag
Human OX40L Protein; His Tag	Human OX40L Protein; mFc Tag
IL-4/IL-13
IL-4 Reporter Cell Line	IL-4/IL-13 Reporter 293 Cell Line	IL-4/IL-13 Reporter 293 DDX35TM Cell Line
Cynomolgus_IL4R CHO-K1 Cell Line	H_IL4R CHO-K1 Cell Line	H_IL4R CHO-K1 Cell Line (Low Expression)
H_IL4R HEK-293 Cell Line	Mouse_IL4R CHO-K1 Cell Line
Biotinylated Human IL-4R alpha Protein; Avi-His Tag	Cynomolgus IL-13 Protein; His Tag	Cynomolgus IL-13RA1 Protein; hFc Tag
Cynomolgus IL-13RA1 Protein; His Tag	Cynomolgus IL-4 Protein; His Tag	Cynomolgus IL-4R alpha Protein; His Tag
Human IL-13 Protein; His Tag	Human IL-13RA1 Protein; hFc Tag	Human IL-13RA1 Protein; His Tag
Human IL-4 Protein; His Tag	Human IL-4R alpha Protein; hFc Tag	Human IL-4R alpha Protein; His Tag
Human IL-4R alpha Protein; mFc Tag	Mouse IL-13 Protein; His Tag	Mouse IL-4R alpha Protein; His Tag
Rat IL-4R alpha Protein; His Tag
IL-31
Cynomolgus_IL-31RA OSMR Reporter Baf3 Cell Line	H_IL-31 Reporter Cell Line	H_IL-31 Reporter DDX35TM Cell Line
Cynomolgus_IL31RA CHO-K1 Cell Line	H_IL31RA CHO-K1 Cell Line	H_IL31RA HEK-293 Cell Line
H_IL-31RA OSMR CHO-K1 Cell Line
Cynomolgus IL-31 Protein; His Tag	Cynomolgus IL-31RA Protein; hFc Tag	Human IL-31 Protein; hFc Tag
Human IL-31 Protein; His Tag	Human IL-31RA Protein; hFc Tag
MRGPRX2
H_MRGPRX2 Gq Reporter CHO-K1 Cell Line	H_MRGPRX2 Gqi5 Reporter CHO-K1 Cell Line	Tango-H_MRGPRX2 CHO-K1 Cell Line
Cynomolgus_MRGPRX2 CHO-K1 Cell Line	Cynomolgus_MRGPRX2 HEK-293 Cell Line	Flag-Mouse_Mrgprb2 CHO-K1 Cell Line
Flag-Rat_Mrgprb3 HEK-293 Cell Line	H_MRGPRX2 CHO-K1 Cell Line	H_MRGPRX2 HEK-293 Cell Line
H_MRGPRX2 HMC-1 Cell Line	H_MRGPRX2 RBL-2H3 Cell Line

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