| Alternative Names | IL-1RAcP, C3orf13, IL1R3 |
| Source | Human IL-1RAP Protein; hFc Tag (GM-88260RP) is expressed from human 293 cells (HEK-293). It contains AA Ser 21 - Glu 359 (Accession # Q9NPH3-1). This protein carries a hFc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 65.1 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-1 RAcP (IL-1 receptor accessory protein), also known as IL-1 R3, is a co-receptor that belongs to the interleukin-1 receptor (IL-1R) superfamily. It is encoded by the IL1RAP gene and is a protein associated with the human immune system and inflammatory responses. IL-1 RAcP protein was initially identified in various immune cells and later detected in multiple tissues including epithelial cells, fibroblasts, and endothelial cells. IL-1 RAcP protein regulates the activation of downstream signaling pathways involved in inflammation and immune responses by associating with the IL-1 receptor type I (IL-1R1) and binding to IL-1 cytokines such as IL-1α and IL-1β. Immune cells and inflammatory mediators are important components of host defense, with critical functions in pathogen clearance, tissue repair, and immune regulation, making them central members of the inflammatory response system. Research indicates that IL-1 RAcP protein plays a significant role in promoting inflammatory signaling, enhancing immune cell activation, and modulating innate immune responses. Additionally, the expression of IL-1 RAcP protein is associated with autoinflammatory diseases, rheumatoid arthritis, and other inflammatory disorders, as well as cancer progression, making it a potential target for immunotherapy and anti-inflammatory therapy. |
| Alternative Names | IL-1RAcP, C3orf13, IL1R3 |
| Source | Human IL-1RAP Protein; hFc Tag (GM-88260RP) is expressed from human 293 cells (HEK-293). It contains AA Ser 21 - Glu 359 (Accession # Q9NPH3-1). This protein carries a hFc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 65.1 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-1 RAcP (IL-1 receptor accessory protein), also known as IL-1 R3, is a co-receptor that belongs to the interleukin-1 receptor (IL-1R) superfamily. It is encoded by the IL1RAP gene and is a protein associated with the human immune system and inflammatory responses. IL-1 RAcP protein was initially identified in various immune cells and later detected in multiple tissues including epithelial cells, fibroblasts, and endothelial cells. IL-1 RAcP protein regulates the activation of downstream signaling pathways involved in inflammation and immune responses by associating with the IL-1 receptor type I (IL-1R1) and binding to IL-1 cytokines such as IL-1α and IL-1β. Immune cells and inflammatory mediators are important components of host defense, with critical functions in pathogen clearance, tissue repair, and immune regulation, making them central members of the inflammatory response system. Research indicates that IL-1 RAcP protein plays a significant role in promoting inflammatory signaling, enhancing immune cell activation, and modulating innate immune responses. Additionally, the expression of IL-1 RAcP protein is associated with autoinflammatory diseases, rheumatoid arthritis, and other inflammatory disorders, as well as cancer progression, making it a potential target for immunotherapy and anti-inflammatory therapy. |
