| Alternative Names | CD213A1, IL-13Ra, NR4, RP13-128O4.2, IL13Rα1 |
| Source | Human IL-13RA1 Protein; hFc Tag (GM-88588RP) is expressed from human 293 cells (HEK-293). It contains AA Gly 22 - Thr 343 (Accession # P78552-1). This protein carries a hFc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 62.8 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-13RA1 protein is a receptor subunit that belongs to the type I cytokine receptor family. It is encoded by the IL13RA1 gene and is a protein associated with the human immune system and allergic responses. IL-13RA1 protein was initially discovered in immune cells such as B cells and monocytes, and later detected in various cell types including epithelial cells, fibroblasts, and smooth muscle cells. IL-13RA1 protein regulates the activation of downstream signaling pathways involved in inflammation and immune regulation by forming a receptor complex with IL-4Rα and binding to its ligands IL-13 and IL-4. B cells, monocytes, and epithelial cells are important components of the immune and respiratory systems, with critical functions in antibody production, pathogen clearance, and tissue homeostasis, making them central members of the inflammatory response system. Research indicates that IL-13RA1 protein plays a significant role in promoting Th2-type immune responses, enhancing mucus production, and modulating allergic inflammation. Additionally, the expression of IL-13RA1 protein is associated with asthma, atopic dermatitis, and other allergic diseases, as well as certain fibrotic disorders and cancers, making it a potential target for immunotherapy and anti-allergic therapy. |
| Alternative Names | CD213A1, IL-13Ra, NR4, RP13-128O4.2, IL13Rα1 |
| Source | Human IL-13RA1 Protein; hFc Tag (GM-88588RP) is expressed from human 293 cells (HEK-293). It contains AA Gly 22 - Thr 343 (Accession # P78552-1). This protein carries a hFc tag at the C-terminus. |
| Purity | > 95% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 62.8 kDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | IL-13RA1 protein is a receptor subunit that belongs to the type I cytokine receptor family. It is encoded by the IL13RA1 gene and is a protein associated with the human immune system and allergic responses. IL-13RA1 protein was initially discovered in immune cells such as B cells and monocytes, and later detected in various cell types including epithelial cells, fibroblasts, and smooth muscle cells. IL-13RA1 protein regulates the activation of downstream signaling pathways involved in inflammation and immune regulation by forming a receptor complex with IL-4Rα and binding to its ligands IL-13 and IL-4. B cells, monocytes, and epithelial cells are important components of the immune and respiratory systems, with critical functions in antibody production, pathogen clearance, and tissue homeostasis, making them central members of the inflammatory response system. Research indicates that IL-13RA1 protein plays a significant role in promoting Th2-type immune responses, enhancing mucus production, and modulating allergic inflammation. Additionally, the expression of IL-13RA1 protein is associated with asthma, atopic dermatitis, and other allergic diseases, as well as certain fibrotic disorders and cancers, making it a potential target for immunotherapy and anti-allergic therapy. |
