| Species Reactivity | Human |
| Clone | spesolimab |
| Source/Isotype | Human IgG1(K214R, L234A, L235A, D356E, L358M), Kappa |
| Application | / |
| Specificity | Detects IL-36R |
| Gene | IL-36R |
| Other Names | IL-1Rrp2, IL1RL2, IL1R-rp2, IL1RRP2 |
| Gene ID | 8808 (human) |
| Background | Spesolimab is the world's first humanized IgG1 monoclonal antibody targeting the interleukin-36 receptor (IL-36R) , developed by Boehringer Ingelheim. As the first drug specifically designed to target the IL-36 pathway, it rapidly clears pustules and improves skin symptoms by specifically blocking the activation of IL-36R and inhibiting downstream pro-inflammatory signaling. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human |
| Clone | spesolimab |
| Source/Isotype | Human IgG1(K214R, L234A, L235A, D356E, L358M), Kappa |
| Application | / |
| Specificity | Detects IL-36R |
| Gene | IL-36R |
| Other Names | IL-1Rrp2, IL1RL2, IL1R-rp2, IL1RRP2 |
| Gene ID | 8808 (human) |
| Background | Spesolimab is the world's first humanized IgG1 monoclonal antibody targeting the interleukin-36 receptor (IL-36R) , developed by Boehringer Ingelheim. As the first drug specifically designed to target the IL-36 pathway, it rapidly clears pustules and improves skin symptoms by specifically blocking the activation of IL-36R and inhibiting downstream pro-inflammatory signaling. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
