| Species Reactivity | Human; Rat; Mouse |
| Clone | 24G3_17C5 |
| Source/Isotype | Human IgG1(KEEM), kappa |
| Application | Flow Cytometry; Bioactivity-ELISA |
| Target | Detects IL1RAP |
| Gene | IL1RAP |
| Other Names | C3orf13, IL-1RAcP, IL1R3 |
| Gene ID | 3556(Human); 25466 (Rat); 16180(Mouse) |
| Background | IL1RAP (Interleukin 1 Receptor Accessory Protein), also known as IL-1R Accessory Protein, belongs to the IL-1 receptor accessory protein family and serves as an important auxiliary protein for IL-1 receptor signaling. IL1RAP forms a receptor complex with IL-1RI (IL-1R1) and other IL-1 family receptors, participating in the signal transduction of ligands such as IL-1β, triggering downstream pathways such as NF-κB and MAPK to regulate inflammatory responses, immune cell activation, and the secretion of inflammatory cytokines. Expression and function of IL1RAP vary by cell type and are tissue-specific; signaling strength can be modulated by alternative splicing variants or post-translational modifications. IL1RAP plays a key role in a variety of inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, and sepsis, by regulating the IL-1 signaling axis to amplify inflammation. Changes in gene expression levels, mutations, or the assembly of receptor complexes in monocytes/macrophages and other immune cells may influence disease susceptibility and progression. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human; Rat; Mouse |
| Clone | 24G3_17C5 |
| Source/Isotype | Human IgG1(KEEM), kappa |
| Application | Flow Cytometry; Bioactivity-ELISA |
| Target | Detects IL1RAP |
| Gene | IL1RAP |
| Other Names | C3orf13, IL-1RAcP, IL1R3 |
| Gene ID | 3556(Human); 25466 (Rat); 16180(Mouse) |
| Background | IL1RAP (Interleukin 1 Receptor Accessory Protein), also known as IL-1R Accessory Protein, belongs to the IL-1 receptor accessory protein family and serves as an important auxiliary protein for IL-1 receptor signaling. IL1RAP forms a receptor complex with IL-1RI (IL-1R1) and other IL-1 family receptors, participating in the signal transduction of ligands such as IL-1β, triggering downstream pathways such as NF-κB and MAPK to regulate inflammatory responses, immune cell activation, and the secretion of inflammatory cytokines. Expression and function of IL1RAP vary by cell type and are tissue-specific; signaling strength can be modulated by alternative splicing variants or post-translational modifications. IL1RAP plays a key role in a variety of inflammatory diseases, including rheumatoid arthritis, inflammatory bowel disease, psoriasis, and sepsis, by regulating the IL-1 signaling axis to amplify inflammation. Changes in gene expression levels, mutations, or the assembly of receptor complexes in monocytes/macrophages and other immune cells may influence disease susceptibility and progression. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Phosphate-buffered solution, pH 7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
