| Alternative Names | Triggering receptor expressed on myeloid cells 2, TREM-2 |
| Source | Human TREM2 Protein; His Tag (GM-88452RP) is expressed from human 293 cells (HEK-293). It contains AA His 19 - Ser 174 (Accession # Q9NZC2-1). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 18.3 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | TREM2 is a type I transmembrane receptor expressed mainly on myeloid cells, including microglia, macrophages, and dendritic cells. It belongs to the triggering receptor expressed on myeloid cells (TREM) family and forms a signaling complex with the adaptor protein DAP12 (TYROBP). TREM-2 plays a key role in modulating innate immune responses, promoting phagocytosis, and influencing microglial activation and survival. Genetic variants in TREM2 have been linked to increased risk of neurodegenerative diseases, including Alzheimer's disease, underscoring its importance in CNS homeostasis and inflammation. TREM-2 associates with DAP12, whose ITAM is phosphorylated to recruit Syk kinase and propagate signaling cascades. This leads to activation of downstream pathways such as PI3K-Akt, ERK, and NF-κB, promoting cytoskeletal rearrangements, phagocytosis, and anti-inflammatory responses. In microglia, TREM-2 signaling supports debris clearance and neuronal support, while certain mutations or dysregulation can impair microglial function and contribute to neurodegenerative pathology. |
| Alternative Names | Triggering receptor expressed on myeloid cells 2, TREM-2 |
| Source | Human TREM2 Protein; His Tag (GM-88452RP) is expressed from human 293 cells (HEK-293). It contains AA His 19 - Ser 174 (Accession # Q9NZC2-1). This protein carries a His tag at the C-terminus. |
| Purity | > 90% as determined by SDS-PAGE |
| Endotoxin | < 1 EU/μg, determined by LAL gel clotting assay |
| Predicted Mol Mass | 18.3 KDa |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Description | TREM2 is a type I transmembrane receptor expressed mainly on myeloid cells, including microglia, macrophages, and dendritic cells. It belongs to the triggering receptor expressed on myeloid cells (TREM) family and forms a signaling complex with the adaptor protein DAP12 (TYROBP). TREM-2 plays a key role in modulating innate immune responses, promoting phagocytosis, and influencing microglial activation and survival. Genetic variants in TREM2 have been linked to increased risk of neurodegenerative diseases, including Alzheimer's disease, underscoring its importance in CNS homeostasis and inflammation. TREM-2 associates with DAP12, whose ITAM is phosphorylated to recruit Syk kinase and propagate signaling cascades. This leads to activation of downstream pathways such as PI3K-Akt, ERK, and NF-κB, promoting cytoskeletal rearrangements, phagocytosis, and anti-inflammatory responses. In microglia, TREM-2 signaling supports debris clearance and neuronal support, while certain mutations or dysregulation can impair microglial function and contribute to neurodegenerative pathology. |
