| Species Reactivity | Human |
| Clone | sibeprenlimab |
| Source/Isotype | Human IgG2, kappa |
| Application | Bioactivity-ELISA |
| Target | Detects APRIL |
| Gene | APRIL |
| Other Names | TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2 |
| Gene ID | 8741 (Human) |
| Background | APRIL is a type II TNF superfamily membrane protein encoded by TNFSF13 (also TNFSF13A). It is expressed in various immune and some non-hematopoietic cells. It exists in membrane-bound and soluble forms (soluble via shedding). APRIL promotes B cell survival, maturation, differentiation, and immunoglobulin production; its dysregulation is linked to autoimmunity and certain hematologic cancers.APRIL binds primarily to TACI and BCMA receptors, activating canonical and noncanonical NF-κB and MAPK pathways. This upregulates anti-apoptotic genes (e.g., BCL2 family) and plasma cell differentiation factors, supporting long-lasting humoral responses. APRIL can cooperate with BAFF to modulate signaling. Dysregulated APRIL–receptor signaling is associated with autoimmunity, making it a therapeutic target in diseases like SLE and monoclonal gammopathies. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human |
| Clone | sibeprenlimab |
| Source/Isotype | Human IgG2, kappa |
| Application | Bioactivity-ELISA |
| Target | Detects APRIL |
| Gene | APRIL |
| Other Names | TNFSF13,TALL-2,TRDL-1,CD256,TALL2,ZTNF2 |
| Gene ID | 8741 (Human) |
| Background | APRIL is a type II TNF superfamily membrane protein encoded by TNFSF13 (also TNFSF13A). It is expressed in various immune and some non-hematopoietic cells. It exists in membrane-bound and soluble forms (soluble via shedding). APRIL promotes B cell survival, maturation, differentiation, and immunoglobulin production; its dysregulation is linked to autoimmunity and certain hematologic cancers.APRIL binds primarily to TACI and BCMA receptors, activating canonical and noncanonical NF-κB and MAPK pathways. This upregulates anti-apoptotic genes (e.g., BCL2 family) and plasma cell differentiation factors, supporting long-lasting humoral responses. APRIL can cooperate with BAFF to modulate signaling. Dysregulated APRIL–receptor signaling is associated with autoimmunity, making it a therapeutic target in diseases like SLE and monoclonal gammopathies. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
