| Species Reactivity | Human |
| Clone | AL002 |
| Source/Isotype | Human IgG1(KDEL),Kappa |
| Application | Activation assay; Flow Cytometry |
| Target | Detects TREM2 |
| Gene | TREM2 |
| Other Names | PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c |
| Gene ID | 54209 (human) |
| Background | Trem2(Triggering Receptor Expressed on Myeloid Cells 2) gene is located on human genome 6q21.1, encoding a transmembrane Receptor protein belonging to immunoglobulin superfamily, which is mainly Expressed on the surface of Myeloid Cells such as microglia and macrophages, in particular, it plays a key role in specific organs such as brain, bone and adipose tissue. This gene binds to adaptor protein DAP12(DNAX-activating protein of 12 kDa) through transmembrane domain to form a signaling complex, which activates downstream Syk kinase and PI3K pathways, and then regulates cell phagocytosis, inflammation suppression and metabolic processes. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human |
| Clone | AL002 |
| Source/Isotype | Human IgG1(KDEL),Kappa |
| Application | Activation assay; Flow Cytometry |
| Target | Detects TREM2 |
| Gene | TREM2 |
| Other Names | PLOSL2; TREM-2; Trem2a; Trem2b; Trem2c |
| Gene ID | 54209 (human) |
| Background | Trem2(Triggering Receptor Expressed on Myeloid Cells 2) gene is located on human genome 6q21.1, encoding a transmembrane Receptor protein belonging to immunoglobulin superfamily, which is mainly Expressed on the surface of Myeloid Cells such as microglia and macrophages, in particular, it plays a key role in specific organs such as brain, bone and adipose tissue. This gene binds to adaptor protein DAP12(DNAX-activating protein of 12 kDa) through transmembrane domain to form a signaling complex, which activates downstream Syk kinase and PI3K pathways, and then regulates cell phagocytosis, inflammation suppression and metabolic processes. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Supplied as a 0.2 μm filtered solution of PBS, pH 7.2-7.4. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
