| Species Reactivity | Human; Cynomolgus; Mouse |
| Clone | Zilovertamab/Cirmtuzumab |
| Source/Isotype | Monoclonal human IgG1, κ |
| Application | Flow cytometry |
| Specificity | Detects ROR1 |
| Gene | ROR1 |
| Other Names | NTRKR1, dJ537F10.1 |
| Gene ID | NM_005012.4 (Human); XM_015434778.1 (Cynomolgus) ; NM_013845.5 (Mouse) |
| Background | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Phosphate-buffered solution, pH 7.2. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
| Species Reactivity | Human; Cynomolgus; Mouse |
| Clone | Zilovertamab/Cirmtuzumab |
| Source/Isotype | Monoclonal human IgG1, κ |
| Application | Flow cytometry |
| Specificity | Detects ROR1 |
| Gene | ROR1 |
| Other Names | NTRKR1, dJ537F10.1 |
| Gene ID | NM_005012.4 (Human); XM_015434778.1 (Cynomolgus) ; NM_013845.5 (Mouse) |
| Background | This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. |
| Storage | Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw. |
| Formulation | Phosphate-buffered solution, pH 7.2. |
| Endotoxin | < 1 EU/mg, determined by LAL gel clotting assay |
