当前位置:产品中心 > 抗体 > ADC类抗体 > Anti-Dxd Mouse IgG2a Antibody (17D6A4)
Anti-Dxd Mouse IgG2a Antibody (17D6A4)
基本信息

产品编号:GM-60248AB

产品名称:Anti-Dxd Mouse IgG2a Antibody (17D6A4)

目录价:询价


产品配图.jpg

规格货号

GM-60248AB-100        100μg

GM-60248AB-1000      1mg

产品简介

Expression System     CHO

Aggregation               < 5% as determined by SEC-HPLC

Purity                          >95% as determined by SDS-PAGE

Endotoxin                  <1 EU/mg by LAL

Sterility                        0.2 μm Filtered

Target                          DXD (Exatecan derivative for ADC)

Clone                           17D6A4

Alternative Names     /

Source/lsotype           Monoclonal Mouse IgG2a,κ

Application                 ELISA, PK

Description                 Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31 μM), used as a conjugated drug of HER2-targeting ADC (DS-8201a). DXd is a part structure of DS-1062a which is a trophoblast cell surface protein 2 (TROP2)-targeting antibody-drug conjugate (ADC) comprised of a humanized anti-TROP2 monoclonal antibody, enzymatically cleavable peptide-linker, and DXd. DXd is an important part structure of DS-7300a, a novel B7-H3-targeting ADC, using DXd-ADC technology, which is composed of a humanized anti-B7-H3 mAb, an enzymatically cleavable tetra-peptide-based linker, and a potent TOP1 inhibitor, DXd.

Formulation                Dulbecco's phosphate-buffered solution, pH 7.4.

Storage temp.             Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

数据展示

/ueditor/image/20240516/1715845007962281/1deba6b2fd5b797dc697283ac3afb75d.png


/ueditor/image/20240516/1715845026104411/d0eeb3385db96fcb294aa79828ffecd8.png

当前位置:产品中心 > 抗体 > ADC类抗体 > Anti-Dxd Mouse IgG2a Antibody (17D6A4)

Anti-Dxd Mouse IgG2a Antibody (17D6A4)
基本信息

产品编号:GM-60248AB

产品名称:Anti-Dxd Mouse IgG2a Antibody (17D6A4)

目录价:询价


产品配图.jpg

规格货号

GM-60248AB-100        100μg

GM-60248AB-1000      1mg

产品简介

Expression System     CHO

Aggregation               < 5% as determined by SEC-HPLC

Purity                          >95% as determined by SDS-PAGE

Endotoxin                  <1 EU/mg by LAL

Sterility                        0.2 μm Filtered

Target                          DXD (Exatecan derivative for ADC)

Clone                           17D6A4

Alternative Names     /

Source/lsotype           Monoclonal Mouse IgG2a,κ

Application                 ELISA, PK

Description                 Dxd (Exatecan derivative for ADC) is a potent inhibitor of DNA topoisomerase I (IC50: 0.31 μM), used as a conjugated drug of HER2-targeting ADC (DS-8201a). DXd is a part structure of DS-1062a which is a trophoblast cell surface protein 2 (TROP2)-targeting antibody-drug conjugate (ADC) comprised of a humanized anti-TROP2 monoclonal antibody, enzymatically cleavable peptide-linker, and DXd. DXd is an important part structure of DS-7300a, a novel B7-H3-targeting ADC, using DXd-ADC technology, which is composed of a humanized anti-B7-H3 mAb, an enzymatically cleavable tetra-peptide-based linker, and a potent TOP1 inhibitor, DXd.

Formulation                Dulbecco's phosphate-buffered solution, pH 7.4.

Storage temp.             Store at 2-8℃ short term (1-2 weeks).Store at ≤ -20℃ long term. Avoid repeated freeze-thaw.

数据展示

/ueditor/image/20240516/1715845007962281/1deba6b2fd5b797dc697283ac3afb75d.png


/ueditor/image/20240516/1715845026104411/d0eeb3385db96fcb294aa79828ffecd8.png

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