| Species Reactivity | Human |
| Specificity | Detects human SSTR2. It also detects cynomolgus SSTR2. |
| Source/Isotype | Monoclonal human IgG1, κ |
| Other Names | SST2 |
| Gene ID | 6752(human), cynomolgus(102142925) |
| Application | Flow cytometry: 0.5 μg-2 μg /test; FC-Quality tested |
| Background | Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene. The somatostatin receptor 2 (SSTR2), which belongs to the G-protein coupled receptor family, is a protein which is most highly expressed in the pancreas (both alpha- and beta-cells), but also in other tissues such as the cerebrum and kidney and in lower amount in the jejunum, colon and liver. In the pancreas, after binding to somatostatin, it inhibits the secretion of peptide hormones from pancreatic islets. During development, it stimulates neuronal migration and axon outgrowth. The somatostatin receptor 2 is expressed in most tumors. Patients with neuroendocrine tumors that over-express the somatostatin receptor 2 have an improved prognosis. The over expression of SSTR2 in tumors can be exploited to selectively deliver radio-peptides to tumors to either detect or destroy them. Somatostatin receptor 2 also has the ability to stimulate apoptosis in many cells including cancer cells. The somatostatin receptor 2 is also being looked at as a possible target in cancer treatment for its ability to inhibit tumor growth. |
| Storage | Store at +4℃ short term (1-2 weeks). Store at -20℃ long term |
| Formulation | Phosphate-buffered solution, pH 7.2. |
| Species Reactivity | Human |
| Specificity | Detects human SSTR2. It also detects cynomolgus SSTR2. |
| Source/Isotype | Monoclonal human IgG1, κ |
| Other Names | SST2 |
| Gene ID | 6752(human), cynomolgus(102142925) |
| Application | Flow cytometry: 0.5 μg-2 μg /test; FC-Quality tested |
| Background | Somatostatin receptor type 2 is a protein that in humans is encoded by the SSTR2 gene. The somatostatin receptor 2 (SSTR2), which belongs to the G-protein coupled receptor family, is a protein which is most highly expressed in the pancreas (both alpha- and beta-cells), but also in other tissues such as the cerebrum and kidney and in lower amount in the jejunum, colon and liver. In the pancreas, after binding to somatostatin, it inhibits the secretion of peptide hormones from pancreatic islets. During development, it stimulates neuronal migration and axon outgrowth. The somatostatin receptor 2 is expressed in most tumors. Patients with neuroendocrine tumors that over-express the somatostatin receptor 2 have an improved prognosis. The over expression of SSTR2 in tumors can be exploited to selectively deliver radio-peptides to tumors to either detect or destroy them. Somatostatin receptor 2 also has the ability to stimulate apoptosis in many cells including cancer cells. The somatostatin receptor 2 is also being looked at as a possible target in cancer treatment for its ability to inhibit tumor growth. |
| Storage | Store at +4℃ short term (1-2 weeks). Store at -20℃ long term |
| Formulation | Phosphate-buffered solution, pH 7.2. |
